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Tirzepatide has already been approved by the FDA for the management of chronic weight in adults who are either obese or overweight and have at least one condition related to weight

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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial